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KMID : 0354719930170010073
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Journal of Korean Diabetes Association
1993 Volume.17 No. 1 p.73 ~ p.78
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Lowering of Plasma Free Fatty Acids by Acipimox Increase Insulin Sensitivity in Rats
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이기업
서교일/박성우/박경수/이홍규/민헌기
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Abstract
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Background:
@EN Impaired gulcose tolerance and decreased sensitivity to insulin is associated with high plasma free fatty acids (FFA) levels in a variety of endocrine and nutritional disorders. Since Randle et al. initially reported that FFA inhibits glucose
utilization in rat muscles, many studies including ours have demonsrated that the increases in FFA levels lead to a state of insulin resistance.
@ES Methods:
@EN To test whether lowering of plasma FFA levels would increase insulin sensitivity, we examined the effect of acipimox, a new antilipolytic agent, on glucose metabolism in normal rats using euglycemic hyperinsulinemic clamp with the insulin
infusion
rate of 2mU/㎏/min/
@ES Results:
@EN 1) Plasma FFA levels were lower in acipimox-treated rats than in control at basal state (186±27umol/l vs. 545±44umol/l. p<0.05) and during insulin intusion.
2) Glucose infusion rate to maintain the cuglycemia was three-fold higher in the acipimox group compared to the control group (16.4±3.4㎎/㎏/min vs. 5.0±2.4㎎/㎏/min, p<0.005).
3) Isotopic determination of glucose turnover disclosed that both insulin-induced suppression of hepatic glucose production and stimulation of peripheral glucose utilization were affected by acipimox treatment. Among them, the effect on the
hepatic
glucose production was more predominant at the plasma insulin level of about 50uU/ml.
@ES Conclusion:
@EN These results suggest that gulcose-fatty acid cycle is operative at low physiological plasma FFA levels.
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KEYWORD
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